Elevated IL-23R Expression and Foxp3+Rorgt+ Cells in Intestinal Mucosa During Acute and Chronic Colitis

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Elevated IL-23R Expression and Foxp3+Rorγt+ Cells in Intestinal Mucosa During Acute and Chronic Colitis

BACKGROUND IL-23/IL-23R signaling plays a pivotal role during the course of inflammatory bowel diseases (IBD). However, the underlying mechanisms are poorly characterized. Foxp3+ regulatory T cells are critical in the maintenance of gut immune homeostasis and therefore are important in preventing the development of IBD. This study was performed to clarify the association between IL-23/IL-23R si...

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Recent studies have shown that Th17 cells may be involved in the pathological process of acute myeloid leukemia. This CD4+ cell subgroup secretes highly homologous interleukin (IL)-17A and IL-17F, and also expresses IL-23 receptor (IL-23R) on the cell surface. Our study aims to investigate the relationship of IL-17A, IL-17F, and IL23R with disease susceptibility, and clarify the relationship be...

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Before dietary protein or endogenous protein of the alimentary tract can be assimilated, it must be hydrolyzed by intraluminal digestive processes into small peptides and free amino acids. Borgstrom et al. (1) found that in normal subjects, 60 to 80% of 1 g of radioiodinated human serum albumin disappeared at the level of the proximal jejunum. Subsequently, Nixon and Mawer (2,3) measured the pr...

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simulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water

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ژورنال

عنوان ژورنال: Medical Science Monitor

سال: 2016

ISSN: 1643-3750

DOI: 10.12659/msm.896827